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Antitumor Activity of Phytic Acid (Inositol Hexaphosphate) in Murine Transplanted and Metastatic Fibrosarcoma, a Pilot Study
Author(s): Vucenik I, Tomazic VJ, Fabian D, Shamsuddin AM
Source: Cancer Letters. 1992; 65:9-13.
We had previously reported that phytic acid (inositol hexaphosphate
or InsP6), a natural constituent of cereal diet, when administered in
drinking water exerts a consistent antitumor effect on expenmental colon
cancer in vivo. The objective of this study was to determine whether
InsP6 has similar anti-neoplastic effect on other tumor models, such
as murine fibrosarcoma. We report that intraperitoneal injection of
InsP6 reduces growth of subcutaneously transplanted fibrosarcoma (FSA-1)
in mice, prolongs survival of tumor-bearing mice and reduces the number
of pulmonary metastases. Since InsP6 is a common constituent of our
diet and has very little or no toxic effects, in addition to being chemopreventive,
it could have potential use in therapy of cancer as well.
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