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Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate
Author(s): Shamsuddin-A-M, Elsayed-A-M, Ullah-A.
Source: Carcinogenesis 1988 Apr, VOL: 9 (4), P: 577-80, ISSN: 0143-3334.
Epidemiological data demonstrate correlations between dietary factors
and the incidence of large intestinal cancer (LIC). Certain high- fiber
diets are associated with a lower risk of LIC; these high-fiber diets
are also rich in inositol hexaphosphate (IP6 or phytic acid). In a pilot
study, we have used F344 rats to investigate the effect of sodium inositol
hexaphosphate (Na-IP6) prior to (experiment I) and following injections
of the carcinogen azoxymethane (AOM) (experiment II). In experiment
I, rats started on 1% Na-IP6 in drinking water 1 week prior to the carcinogen
treatment showed a 34.7% decrease (P less than 0.01) in LIC compared
to control carcinogen treatment group. A similar reduction in the incidence
of LIC was also observed in experiment II, wherein Na-IP6 supplementation
was started 2 weeks following the last dose of the carcinogen. Comparison
of the incidence of mitosis in the colonic crypts of the animals in
different groups show that animals on AOM + IP6 demonstrate a significantly
lower (P less than 0.001) mitotic rate than those receiving AOM only.
Pilot studies of free radical generation demonstrate a reduction in
.OH radical formation by Na-IP6. Further studies to expand this pilot
data and to understand the mechanism of IP6 mediated LIC suppression
are needed for it may have significance in our strategies for LIC control.
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