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Inositol and inositol hexaphosphate suppress cell proliferation and tumor formation in CD-1 mice
Author(s): Shamsuddin-A-M, Ullah-A, Chakravarthy-A-K.
Source: Carcinogenesis 1989 Aug, VOL: 10 (8), P: 1461-3, ISSN: 0143-3334.
In previous studies, we have shown that inositol hexaphosphate (Ins
P6), a constituent of cereal diet, inhibited azoxymethane-induced experimental
large intestinal cancer (LIC) in Fischer 344 rats. We now report a similar
antineoplastic action of InsP6 in CD-1 mice injected with 1,2-dimethylhydrazine
(DMH). We had hypothesized that InsP6 may bring about this effect by
undergoing dephosphorylation to lower phosphorylated forms; the ready
availability of Ins, to react with phosphates, may increase the total
amount of the lower phosphorylated Ins and potentiate the action of
InsP6. LIC induced by DMH (15 mg/kg/week x 13) in mice given a mixture
of 1% InsP6 + 1% Ins show a significant reduction (P less than 0.005)
in LIC prevalence over InsP6 treatment. Surprisingly, Ins, an in vitro
growth promoting agent also caused a significant (P less than 0.001)
suppression of LIC. InsP6 +/- Ins also showed a concomitant reduction
in the mitotic rate in the non-neoplastic epithelium. Body weight data
did not suggest any overt toxic effect of long-term administration of
InsP6, Ins or InsP6 + Ins. Since InsP6 is antineoplastic in two species
of experimental animals, it should, in combination with Ins, be considered
in our strategies for prevention of large intestinal cancer.
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