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Comparison of Pure Inositol Hexaphosphate and High-Bran Diet in the Prevention of DMBA-Induced Rat Mammary Carcinogenesis
Author(s): Vucenik I, Yang G, Shamsuddin AM
Source: Nutrition and Cancer. 1997; 28(1):7-13.
Inositol hexaphosphate (IP6), abundant in cereals and legumes, has
been demonstrated to be a promising anticancer agent in different in
vivo and in vitro models. Because IP6 is particularly abundant in the
bran part of certain mature seeds such as wheat, we investigated whether
a high-fiber bran diet containing high IP6 shows a dose-response inhibition
of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary carcinogenesis.
Starting at two weeks before DMBA intubation, rats were divided into
five groups and fed AIN-76A diet only or AIN-76A diet containing 5%,
10%, or 20% Kelloggs' All Bran; the fifth group received 0.4% IP6 given
in drinking water, an amount equivalent to the IP6 content in 20% bran.
After carcinogen administration, the rats remained on these regimens
for 29 weeks. Compared with the carcinogen control, at 29th week, tumor
incidence was reduced by 16.7%, 14.6%, and 11.4% in rats fed 5%, 10%,
and 20% bran, respectively (not statistically significant). However,
rats given 0.4% IP6 in drinking water, equivalent to that in 20% bran,
had a 33.5% reduction in tumor incidence (p < 0.02) and 48.8% fewer
tumors (p < 0.03). These data show that supplemental dietary fiber
in the form of bran exhibited a very modest, statistically significant
inhibitory effect, which was also not dose dependent. In contrast, animals
given IP6 showed significant reduction in tumor number, incidence, and
multiplicity. Thus IP6, an active substance responsible for cereal's
beneficial anticancer effect, is clearly more effective than 20% bran
in the diet. In practical terms, intake of IP6 may be a more pragmatic
approach than gorging enormous quantities of fiber for cancer prophylaxis.
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